In the Eulerian approach, both the continuous and dispersed phases are considered to be interpenetrating continua
In the Eulerian-Eulerian (E-E) approach both the dispersed particle phase and continuous fluid phase are solved using the NS
The VOF is applicable for separated flows or stratified or where the dispersed phase is well separated from the continuous phase with a distinct interface
Multi fluid vof model should be enabled only for cases requiring sharp interface treatment between phases.
So it looks like in your case if you have immiscible fluids, you can use vof model.